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Perfil investigador
Esp
Dr. Alma Elizabeth Cruz Guerrero

Professor
Departament of Biotechnology

Division of Biological and Health Sciences


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Iztapalapa Campus

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Sustainable Development Goals

• 3 Good Health and Well-being

• 9 Industry, Innovation and Infrastructure


Research interests

• Enzymatic synthesis of oligosaccharides
• Food enzymology
• Milk technology and dairy products
• Probiotics and prebiotics
• Yeast technology

Profile

Doctor Alma Elizabeth Cruz has developed her career as a Professor-Researcher at the Universidad Autónoma Metropolitana (UAM) in the Biotechnology Department of the Iztapalapa Campus.

She studied for a Bachelor's degree in Food Engineering, a Master's degree in Biotechnology, and a Ph.D. in Biotechnology at UAM. She has been a National System of Researchers member since 2007, currently level II, and has been a Professor with a Desirable Profile since 1996.

Professor Cruz participates as responsible and collaborates in different research projects and agreements with the productive sector; she collaborates with national and international institutions in research projects and as co-director of graduate students. The lines of research in which she has worked are related to enzymology applied to food, yeast science, and technology, science and technology of milk and dairy products, probiotics and prebiotics, enzymatic synthesis of oligosaccharides in aqueous and non-aqueous media, nixtamalization technology, presence of aflatoxins in dairy products.

The result of her current scientific production is based on the trajectory of her cooperation with different research groups: Food Biotechnology (UAM Iztapalapa Campus), the research group of the Universidad Autónoma de Hidalgo, with professors from IBT, Universidad Nacional Autónoma de México (UNAM), with researchers from CIAD (Hidalgo) and Colegio de Posgraduados (Chapingo). This trajectory has led her to have a total of 52 publications, including articles and book chapters, one patent, human resources training, 60 social services, 14 research stays, eight undergraduate theses, nine specialization theses, 16 master's and doctoral theses, more than 100 presentations in national and international forums, 13 dissemination articles and multiple participations in project evaluation committees and national and international publications.

She has collaborated in agreements with the productive sector with the following companies: Ácidos Orgánicos, in the biochemical and functional characterization of yeast strains for baking; Unión General de obreros y campesinos de México, projects were carried out for the production of maguey honey, fruit canning and whey; Centro de Control S.A., in advisory services for arbitration on the quality of milk and dairy products; Comercializadora de Lácteos y Derivados S.A., under the project entitled "Increasing the production capacity of fermented milk beverages"; and Centro de Control S.A., under the project entitled "Increasing the production capacity of fermented milk beverages".

Concerning university participation, she was a coordinator of the Food Engineering degree, a member of the Divisional Review Commission, has participated in the commissions for the revision of study plans and programs of the Food Engineering degree, member of the commission of the Biotechnology Graduate Program in two periods, has participated in the commissions for the revision of study plans and programs of the Biotechnology Graduate Program.



Information provided by the academic staff

Research interests

• Enzymatic synthesis of oligosaccharides
• Food enzymology
• Milk technology and dairy products
• Probiotics and prebiotics
• Yeast technology

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAGranados-Martínez, M., Guzmán-Rodríguez, F., Cruz-Guerrero, A. and 1 more (...) (2026).Valorization of requesón Cheese Whey through Synthesis of Galactooligosaccharides with Fungal and Recombinant β-Galactosidases. ACS Food Science and Technology,6(4) 986-995| 9 |
OAPatlan-Velázquez, L.-F., González-Olivares, L.-G., García-Garibay, M. and 5 more (...) (2026).Bioactive Peptide-Enriched Requeson: A Functional Dairy Product From Whey Fermentation. Food Science and Nutrition,14(4) | 12 |
OACarrero-Puentes, S., Jiménez-Pérez, C., Guzmán-Rodríguez, F. and 6 more (...) (2025).Effect of an exopolysaccharide-producing strain of Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772 on the yield and quality of Requeson (Mexican cheese) added with a probiotic. Journal of Dairy Research,92(4) 566-573
OAPatlan-Velazquez, L.F., González-Olivares, L.G., García-Garibay, M. and 4 more (...) (2025).Whey as a substrate for biogenic production of exopolysaccharide. Revista Mexicana de Ingeniera Quimica,24(1)
Hernández-Martínez, A., Roldán-Hernández, L., Razmkhah, K. and 4 more (...) (2025).Evaluation of aflatoxin M1 binding capacity of kefir exopolysaccharides produced with different fermentation media. International Dairy Journal,169
Martha-Lucero, N., Cruz-Guerrero, A., Favela-Torres, E. and 3 more (...) (2025).Lactic acid production by direct fermentation of agave fructans. Journal of Chemical Technology and Biotechnology,100(5) 935-941| 9 |
OARobles-Arias, M., Cruz-Guerrero, A. (2025).Design of an enzymatic process for the obtention of short-chain fructooligosaccharides from Agave salmiana leaves. Food Bioscience,71| 9 | 12 |
Robles-Arias, M.A., Jímenez-Pérez, C., Gómez-Castro, C.Z. and 7 more (...) (2025).Effect of temperature on the structure of α-l-fucosidase from Thermotoga maritima: implications from molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics,| 3 |
OAGallardo-Martínez, D., Viniegra-González, G., Figueroa-Martínez, F. and 2 more (...) (2024).Isolation and characterization of epiphytic, fructanolytic, homofermentative lactic acid bacteria from Agave salmiana. Revista Mexicana de Ingeniera Quimica,23(1)
OARobles-Arias, M., Guzmán-Rodríguez, F., Cruz-Guerrero, A. (2024).Evaluation of the Suitability of Agave salmiana Leaves for Fructooligosaccharydes Recovery. ACS Food Science and Technology,4(7) 1626-1631
OAGuzmán-Rodríguez, F., Gómez-Ruiz, L., Cruz-Guerrero, A. (2024).Antithrombotic and ACE-inhibitory activity of milk fermented by Lacticaseibacillus rhamnosus GG and Lactobacillus delbrueckii ssp. bulgaricus. International Journal of Food Science and Technology,59(12) 9417-9424
OAJiménez-Pérez, C., Roldán-Hernández, L., Cruz-Guerrero, A. and 1 more (...) (2024).Evaluation of the aflatoxin M1 retention capacity in a polysaccharide obtained by fermenting milk with kefir grains. Revista Mexicana de Ingeniera Quimica,23(2) | 9 |
OAAlcantar-Morales, S.L., Ramírez-Ortiz, A., Gallardo-Martínez, D. and 3 more (...) (2024).Kinetics and microbiology of pulp silage from decorticated Agave salmiana leaves. Mexican Journal of Biotechnology,9(4) 14-29| 15 |
OAHernández-Riveros, E., Olvera-Rosales, L.B., Jaimez-Ordaz, J. and 4 more (...) (2024).Production of an Ice Cream Base with Added Lacticaseibacillus rhamnosus GG and Aguamiel Syrup: Probiotic Viability and Antihypertensive Capacity. Dairy,5(3) 451-463
Patlan-Velázquez, L.-F., González-Olivares, L.-G., García-Garibay, M. and 4 more (...) (2024).Effect of biogenic exopolysaccharides in characteristics and stability of a novel Requeson-type cheese. Food Bioscience,59
Guzmán-Rodríguez, F., Alatorre-Santamaría, S., Cruz-Guerrero, A. (2023).Human Milk Oligosaccharides (HMOS). Handbook of Food Bioactive Ingredients: Properties and Applications,1383-1411
Cruz-Guerrero, A., Gómez-Ruiz, L., Guzmán-RodrÍguez, F. (2023).Xylooligosaccharides (XOS). Handbook of Food Bioactive Ingredients: Properties and Applications,1243-1269| 3 |
Alatorre-Santamaría, S., Cruz-Guerrero, A., Guzmán-Rodríguez, F. (2023).Fructooligosaccharides (FOS). Handbook of Food Bioactive Ingredients: Properties and Applications,1271-1300| 3 |
Martha-Lucero, N., Viniegra-González, G., González-Olivares, L. and 1 more (...) (2023).Biofilm formation by agave epiphytic lactic acid bacteria fed with agave fructans. World Journal of Microbiology and Biotechnology,39(11)
OAJiménez-Pérez, C., Guzmán-Rodríguez, F., Cruz-Guerrero, A.E. and 1 more (...) (2023).The dual role of fucosidases: tool or target. Biologia,78(7) 1773-1788| 3 |
Olvera-Rosales, L.B., Cruz-Guerrero, A.E., García-Garibay, J.M. and 4 more (...) (2023).Bioactive peptides of whey: obtaining, activity, mechanism of action, and further applications. Critical Reviews in Food Science and Nutrition,63(30) 10351-10381
OAOlvera-Rosales, L.B., Pérez-Escalante, E., Castañeda-Ovando, A. and 5 more (...) (2023).ACE-Inhibitory Activity of Whey Proteins Fractions Derived of Fermentation by Lacticaseibacillus rhamnosus GG and Streptococcus thermophilus SY-102. Foods,12(12)
OAPavón-Chimal, M.E., Jiménez-Pérez, C., Guzmán-Rodríguez, F. and 6 more (...) (2023).An In silico Analysis of Enzyme-Substrate Interaction in α-L-Fucosidases Belonging to the GH29 Family. Biointerface Research in Applied Chemistry,13(5)
Pavón-Chimal, M.E., Jiménez-Pérez, C., Guzmán-Rodriguez, F. and 6 more (...) (2023).Mechanistic insight into the synthesis of fucooligosaccharides by α-L-fucosidase from Thermotoga maritima belonging to the GH29 family: in silico study. Biologia,78(7) 1825-1832
OACastañeda-Ovando, A., Moreno-Vilet, L., Jaimez-Ordaz, J. and 7 more (...) (2023).Aguamiel syrup as a technological diversification product: Composition, bioactivity and present panorama. Future Foods,8| 3 |
OAOlvera-Rosales, L.B., Cruz-Guerrero, A.E., Jaimez-Ordaz, J. and 5 more (...) (2023).Differences in the Proteolytic System of Lactic Acid Bacteria Affect the Release of DPP-IV Inhibitory Peptides from Whey Proteins. Dairy,4(3) 515-526
Carrero-Puentes, S., Fuenmayor, C., Jiménez-Pérez, C. and 6 more (...) (2022).Development and characterization of an exopolysaccharide-functionalized acid whey cheese (requesón) using Lactobacillus delbrueckii ssp. bulgaricus. Journal of Food Processing and Preservation,46(6)
Pérez-Escalante, E., Alatorre-Santamaría, S., Castañeda-Ovando, A. and 5 more (...) (2022).Human milk oligosaccharides as bioactive compounds in infant formula: recent advances and trends in synthetic methods. Critical Reviews in Food Science and Nutrition,62(1) 181-214
OAde la Vega, M.I.C., Alatorre-Santamaría, S., Gómez-Ruiz, L. and 5 more (...) (2021).Influence of oat β-glucan on the survival and proteolytic activity of lactobacillus rhamnosus gg in milk fermentation: Optimization by response surface. Fermentation,7(4)
Guzmán-Rodríguez, F., Alatorre-Santamaría, S., Gómez-Ruiz, L. and 3 more (...) (2021).Synthesis of fucosylated oligosaccharides with α-l-fucosidase from Thermotoga maritima immobilized on Eupergit® CM. Extremophiles,25(3) 311-317
OARobles-Arias, M.A., Guzmán-Rodriguez, F., García-Garibay, M. and 4 more (...) (2021).α-L-fucosidase from Thermotoga maritima: Hydrolytic and transfucosylation activities. Revista Mexicana de Ingeniera Quimica,20(3)
OAContreras-López, E., Jaimez-Ordaz, J., Rodríguez-Serrano, G.M. and 4 more (...) (2021).Contenido exopolysaccharide-producing bacteria improves survival and proteolytic profile of lactobacillus rhamnosus gg added to semi-ripened cheese volumen 8, número 3, 2009 / volume 8, number 3, 2009. Revista Mexicana de Ingeniera Quimica,20(3)
Jiménez-Pérez, C., Alatorre-Santamaría, S., Tello-Solís, S.R. and 4 more (...) (2021).Analysis of aflatoxin m1 contamination in milk and cheese produced in mexico: A review. World Mycotoxin Journal,14(3) 269-285
Robles-Arias, M.A., García-Garibay, M., Alatorre-Santamaría, S. and 5 more (...) (2021).Improvement of Fucosylated Oligosaccharides Synthesis by α-L-Fucosidase from Thermotoga maritima in Water-Organic Cosolvent Reaction System. Applied Biochemistry and Biotechnology,193(11) 3553-3569
OASebastián-Nicolas, J.L., Contreras-López, E., Ramírez-Godínez, J. and 8 more (...) (2021).Milk fermentation by lacticaseibacillus rhamnosus GG and streptococcus thermophilus SY-102: Proteolytic profile and ACE-inhibitory activity. Fermentation,7(4)
OAOlvera-Rosales, L.-B., Cruz-Guerrero, A.-E., Ramírez-Moreno, E. and 8 more (...) (2021).Impact of the gut microbiota balance on the health-disease relationship: The importance of consuming probiotics and prebiotics. Foods,10(6) | 3 |
Jiménez-Pérez, C., Tello-Solís, S.R., Gómez-Castro, C.Z. and 6 more (...) (2020).Spectroscopic studies and molecular modelling of the aflatoxin M1-bovine α-lactalbumin complex formation. Journal of Photochemistry and Photobiology B: Biology,209
OASebastián-Nicolás, J.L., Cruz-Guerrero, A.E., Castañeda-Ovando, A. and 4 more (...) (2020).Enrichment of lactoferrin by a simple process based on solid phase extraction. Revista Mexicana de Ingeniera Quimica,19(1) 239-249| 3 |
Sebastián-Nicolás, J.L., González-Olivares, L.G., Vázquez-Rodríguez, G.A. and 3 more (...) (2020).Valorization of whey using a biorefinery. Biofuels, Bioproducts and Biorefining,14(5) 1010-1027| 7 |
Pérez-Escalante, E., Cruz-Guerrero, A.E., Álvarez-Romero, G.A. and 3 more (...) (2020).Urea as the best fibrin solubilizer in the thrombin inhibition analysis: Theoretical and experimental modeling of fibrinogen denaturation. Chemical Physics Letters,748

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26I
Trabajo Experimental IVPosgrado
2
26I
Trabajo Experimental IXPosgrado
3
26I
Trabajo Experimental VIPosgrado
4
26I
Trabajo Experimental VIPosgrado
5
26I
Trabajo Experimental VIPosgrado
6
26I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
7
25O
Seminario de Proyecto DoctoralPosgrado
8
25O
Trabajo Experimental VPosgrado
9
25O
Trabajo Experimental VPosgrado
10
25O
Trabajo Experimental VPosgrado
11
25O
Trabajo Experimental VIIIPosgrado
12
25P
Tecnología EnzimáticaLicenciatura
13
25P
Trabajo Experimental VIIPosgrado
14
25P
Trabajo Experimental IVPosgrado
15
25P
Trabajo Experimental IVPosgrado
16
25P
Seminario de Informe TerminalPosgrado
17
25P
Química y Enzimología de AlimentosLicenciatura
18
25I
Química y Enzimología de AlimentosLicenciatura
19
25I
Seminario de Informe TerminalPosgrado
20
25I
Seminario de Proyecto DoctoralPosgrado
21
25I
Seminario de Proyecto DoctoralPosgrado
22
25I
Tecnología EnzimáticaLicenciatura
23
25I
Trabajo Experimental IIIPosgrado
24
25I
Trabajo Experimental VIPosgrado
25
24O
Trabajo Experimental IIPosgrado
26
24O
Trabajo Experimental XIIPosgrado
27
24O
Trabajo Experimental VPosgrado
28
24O
Química y Enzimología de AlimentosLicenciatura
29
24P
Química y Enzimología de AlimentosLicenciatura
30
24P
Seminario de Informe TerminalPosgrado
31
24P
Seminario de Informe TerminalPosgrado
32
24P
Seminario de Informe TerminalPosgrado
33
24P
Trabajo Experimental IPosgrado
34
24P
Trabajo Experimental IVPosgrado
35
24P
Trabajo Experimental XIPosgrado
36
24P
Química y Bioquímica de AlimentosPosgrado
37
24I
Seminario de Proyecto DoctoralPosgrado
38
24I
Trabajo Experimental XIIPosgrado
39
24I
Trabajo Experimental XIIPosgrado
40
24I
Trabajo Experimental XPosgrado
41
24I
Trabajo Experimental IIIPosgrado
42
24I
Trabajo Experimental IIIPosgrado
43
24I
Trabajo Experimental IIIPosgrado
44
24I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
45
24I
Química y Enzimología de AlimentosLicenciatura
46
23O
Trabajo Experimental IIPosgrado
47
23O
Trabajo Experimental IIPosgrado
48
23O
Trabajo Experimental XIPosgrado
49
23O
Trabajo Experimental XIPosgrado
50
23O
Tecnología EnzimáticaLicenciatura
51
23O
Tópicos en Biotecnología IPosgrado
52
23O
Tópicos de Biotecnología IIPosgrado
53
23O
Química y Enzimología de AlimentosLicenciatura
54
23O
Trabajo Experimental IIPosgrado
55
23P
Trabajo Experimental XPosgrado
56
23P
Trabajo Experimental IXPosgrado
57
23P
Trabajo Experimental IPosgrado
58
23P
Trabajo Experimental IPosgrado
59
23P
Trabajo Experimental IPosgrado
60
23P
Tópicos en Biotecnología IPosgrado
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Universidad Autónoma Metropolitana, 2026.